A Novel Solvent System to Prepare Pellets of Active Pharmaceutical Ingredients Having Tacky Wet-Mass Forming Propensity By Extrusion Spheronization Technique

Preparation and evaluation of carvacrol pellets based on PVP solid-dispersion by extrusion-spheronization technique

Background and objectives: Carvacrol is one of the main pharmacologically active components of Thymus vulgaris essential oil which has shown several therapeutic effects. There are few works regarding the formulation of essential oils as oral solid dosage forms due to their liquid nature, stability and technical problems. The aim of this study was to combine the solid-d...

Determination of Moisture Requirement to Prepare Spheroids by Extrusion-spheronization

Development and evaluation of omeprazole pellets fabricated by sieving-spheronization and extrusion - spheronization process.

Pelletized dosage forms can be prepared by different methods which, in general, are time consuming and labor intensive. The current study was carried out to investigate the feasibility of preparing the spherical pellets of omeprazole by sieving-spheronization. An optimized formulation was also prepared by extrusion-spheronization process to compare the physical parameters between these two meth...

In vitro Release Kinetics Study of Ambroxol Hydrochloride Pellets Developed by Extrusion Spheronization Technique Followed by Acrylic Polymer Coating

The aim of the present study was to investigate the effect of Ammonio Methacrylate Copolymer Dispersion Type A (Eudragit RL 30 D) and Ammonio Methacrylate Copolymer Dispersion Type B (Eudragit RS 30 D) combination in different weight ratios on the release kinetics of Ambroxol Hydrochloride from coated pellets. Microcrystalline cellulose, lactose, maize starch, hydroxypropyl methylcellulose and ...

Extrusion Spheronization –A Review

Compared to single-unit dosage forms, oral multiparticulate drug-delivery systems (e.g. pellets, granules) offer biopharmaceutical advantages in terms of a more even and predictable distribution and transportation in the gastrointestinal tract. There are different pelletization and granulation techniques available to prepare drug loaded spherical particles or granules. Extrusion Spheronization ...